Its innovative mechanism of action acts on keratinocytes4 (fig. 1), inhibiting the release of melanocyte stimulating agents and factors triggering the inflammatory and vascular process: prostaglandins (PG)5-8 and endothelin-1 (ET-1)9-11.

1. Vascularisation: It reduces the excessive vascularisation that characterises some recurrent hyperpigmentations, such as melasma..
2. Inflammation: It acts on the inflammatory process that occurs after external aggressions, skin lesions (acne, scars) or medical-cosmetic treatments, such as laser or photodepilation.
3. Pigmentation: It regulates effectively the melanogenesis process by reducing the amount and activity of tyrosinase, avoiding proliferation of melanocytes
   and reducing their dendricity.